This test could be used to stimulate a normal suppressed thyroid gland in presence of a hot autonomous nodule and demonstrate dependence to TSH.

            Two protocols have been used to stimulate the thyroid. One with bovine TSH and the other one with a Synthetic product, detailed below.

1) TSH (Bovine Thyroid Stimulating Hormone):

- 10 uIU im x 3 days, prior to uptake test.

2) Thyrogen (Recombinant Thyroid Stimulating  Hormone) Package Insert :

- 0,9 mg im every 24h x 2 doses, prior to control uptake test.

or

- 0,9 mg im every 72h x 3 doses, prior to control uptake test.

Park HM, The Thyroid Gland in Henkin RE et al. Nuclear Medicine. Mosby St Louis 1996, p 836.