TRODAT NORMAL IMAGES
In a normal subject, it can be seen intense uptake in striatal substance in the basal nuclei. Slight asymmetry of uptake can be found in the striatum. There is also relative good uptake both in anterior and posterior striatum. Minimun activity in the surrounding brain in transaxial slice (with permission www.alasbimnjournal.cl). Using a template it could be possible to assess the caudate and putamen for quantitative indexes (1).
Quantitative parameters may be obtained from normal subjects, but are not reproducible or discriminant enough to be of help in the evaluation of individual cases (2-4). Therefore, visual assessment alone can be used in clinical practice.
References:
1 Mena, Ismael, Diaz, Fernando y Gomez, Ariel. Diagnóstico precoz de Enfermedad de Parkinson : Trodat-1 Tc99m. Hemiparkinsonismo. Alasbimn Journal 3(10): January 2001. http://www.alasbimnjournal.cl/revistas/10/mena.html.
2 P. David Mozley, Jay S. Schneider, Paul D. Acton, Karl Plossl, Matthew B. Stem, Andrew Siderowf, Norman A. Leopold, Pei Yong Li, Abass Alavi, and Hank F. Kung. Binding of [99mTc]TRODAT-1 to Dopamine Transporters in Patients with Parkinson's Disease and in Healthy Volunteers.J Nucl Med 2000; 41: 584-589.
3 Chou K.L., Hurtig, HI., Stern, M.B., Colcher, A., Ravina,B., Newberg A., Mozley P.D., Siderowf, A.. Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson’s disease. Parkinsonism and Related Disorders 2004; 10: 375–379.
4 Andre C. Felicio, Clecio Godeiro-Junior, Ming C. Shih, Vanderci Borges, Sônia M.A. Silva, Patrícia de Carvalho Aguiar, Marcelo Q. Hoexter, Orlando G.P. Barsottini, Luiz A.F. Andrade, Rodrigo A. Bressan, Henrique B. Ferraz. Evaluation of patients with Clinically Unclear Parkinsonian Syndromes submitted to brain SPECT imaging using the technetium-99m labeled tracer TRODAT-1. Journal of the Neurological Sciences 2010; 291: 64–68.