bone marrow DIFFUSE UPTAKE
Date: 16.11.2004. FDG Dose: 14 mCi, injected with bgl of 87 mg / dL.
Patient 44 year old, with a history of right breast cancer (invasive
adenocarcinoma) diagnosed clinical stage III in September 2004, not operated.
Being treated with adjuvant chemotherapy, four cycles, Neupogen and
erythropoietin. In control CT presents with a suspicious lesion in right lung
base. FINDINGS: Diffuse increased activity of the radionuclide in bone marrow
and spleen, due to treatment. In the remainder of the study, regular
distribution is observed in brain, lungs, axillary regions, mediastinum, liver,
colon, kidneys, pyelocalicial systems and bladder .
Date:
15.03.2006: FDG Dose: 14 mCi, injected with bgl of 88 mg / dL. Patient 46 years
of age. Chemotherapy ends in January 2005 followed by total mastectomy and
axillary lymphadenectomy. Restaging. FINDINGS: Regarding previous study in
November 2004, it shows normal distribution.
They report a case of leukemia in which
diffuse bone marrow uptake of FDG was observed, and bone marrow aspiration
subsequently revealed acute lymphoblastic leukemia. It is not easy to
differentiate between physiological and pathologic uptake when diffuse
homogeneous uptake in bone marrow is observed (1-4).
References:
1.Su K, Nakamoto Y, Nakatani K, Kurihara K, Hayakawa N, Togashi K. Diffuse Homogeneous Bone Marrow Uptake of FDG in Patients With Acute Lymphoblastic Leukemia. Clin Nucl Med. 2013 Jan;38(1):e33-4.
2. Kazama H, Teramura M, Yoshinaga K, Masuda A, Motoji T. Long-term remission of primary bone marrow diffuse large B-cell lymphoma treated with high-dose chemotherapy rescued by in vivo rituximab-purged autologous stem cells. Case Report Med. 2012;2012:957063. Epub 2012 Oct 16.
3. Koga T, Umeda M, Migita K, Yamasaki S, Nakamura
H, Kawakami A. A Japanese case of familial Mediterranean fever presenting
diffuse bone marrow uptake of FDG-PET and high levels of neutrophil membrane
CD64 expression. Rheumatology. 2011 Jun;50(6):1171-3. Epub 2011 Feb 4.
4. Kazama T, Swanston N, Podoloff DA, Macapinlac HA . Effect of colony-stimulating
factor and conventional- or high-dose chemotherapy on FDG uptake in bone marrow.
Eur J Nucl Med Mol Imaging 2005;32:1406-11.