bone marrow DIFFUSE UPTAKE

 

 

 

 

 

 

 

 

 

 

 

 

            Date: 16.11.2004. FDG Dose: 14 mCi, injected with bgl of 87 mg / dL.  Patient 44 year old, with a history of right breast cancer (invasive adenocarcinoma) diagnosed clinical stage III in September 2004, not operated. Being treated with adjuvant chemotherapy, four cycles, Neupogen and erythropoietin. In control CT presents with a suspicious lesion in right lung base. FINDINGS: Diffuse increased activity of the radionuclide in bone marrow and spleen, due to treatment. In the remainder of the study, regular distribution is observed in brain, lungs, axillary regions, mediastinum, liver, colon, kidneys, pyelocalicial systems and bladder .
            Date: 15.03.2006: FDG Dose: 14 mCi, injected with bgl of 88 mg / dL. Patient 46 years of age. Chemotherapy ends in January 2005 followed by  total mastectomy and axillary lymphadenectomy. Restaging. FINDINGS: Regarding previous study in November 2004, it shows  normal distribution.

             They report a case of leukemia in which diffuse bone marrow uptake of FDG was observed, and bone marrow aspiration subsequently revealed acute lymphoblastic leukemia. It is not easy to differentiate between physiological and pathologic uptake when diffuse homogeneous uptake in bone marrow is observed (1-4).
 

References:

1.Su K, Nakamoto Y, Nakatani K, Kurihara K, Hayakawa N, Togashi K.  Diffuse Homogeneous Bone Marrow Uptake of FDG in Patients With Acute Lymphoblastic Leukemia. Clin Nucl Med. 2013 Jan;38(1):e33-4.

2. Kazama H, Teramura M, Yoshinaga K, Masuda A, Motoji T. Long-term remission of primary bone marrow diffuse large B-cell lymphoma treated with high-dose chemotherapy rescued by in vivo rituximab-purged autologous stem cells. Case Report Med. 2012;2012:957063. Epub 2012 Oct 16.

3. Koga T, Umeda M, Migita K, Yamasaki S, Nakamura H, Kawakami A. A Japanese case of familial Mediterranean fever presenting diffuse bone marrow uptake of FDG-PET and high levels of neutrophil membrane CD64 expression. Rheumatology. 2011 Jun;50(6):1171-3. Epub 2011 Feb 4.

4. Kazama T, Swanston N, Podoloff DA, Macapinlac HA . Effect of colony-stimulating factor and conventional- or high-dose chemotherapy on FDG uptake in bone marrow. Eur J Nucl Med Mol Imaging 2005;32:1406-11.

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