(Prepared by Dr Jaime Carmona)
Female, 61 year old, diagnosed with right breast
cancer (moderately differentiated invasive ductal carcinoma, with involvement of
skin). PET-FDG with 12 mCi, injected with blood glucose level of 96 mg/dl showed
in multiple focus of intense increased right breast tracer uptake
anteriorly, associated with a posterior horizontal mass with irregular borders
which measures 7 x 3.5 cm, maximun SUV uptake of 12 (black arrows). In addition,
there are at least 4 areas of radiopharmaceutical uptake in right axillary
region, the largest 9 mm and maximun SUV of 5.8, and another focus
ipsilateral supraclavicular of 1.5 cm maximun SUV of 5.8 (red arrows).
In 11 patients, Azuma et al., found that tumor cell density of intraductal
carcinoma appears strongly correlated to detection by FDG-PET/CT (1).
Adler
at al conclude that FDG-based lesion with dedicated positron emission
mammography localization information may be combined with the lesion X-ray
attenuation characteristics using this common imaging platform (2).
References:
1 Azuma A, Tozaki M, Ito K, Fukuma E, Tanaka T, O'uchi T. Ductal carcinoma in situ: correlation between FDG-PET/CT and histopathology. Radiat Med. 2008 Oct;26(8):488-93.
2 Adler LP, Weinberg IN, Bradbury MS, Levine EA, Lesko NM, Geisinger KR, Berg WA, Freimanis RI. Method for combined FDG-PET and radiographic imaging of primary breast cancers. Breast J. 2003 May-Jun;9(3):163-6.