Lung Carcinoma
Bone scan is a well established procedure in the diagnosis of lung skeletal metastasis. After prostate and breast cancer it follows in frequency as an accepted application.
Tao Liu 1. et al. in a meta analysis on MRI, PET FDG and Bone Scan concluded that 18FDG PET was found to be the best modality to detect bone metastasis in patients with lung cancer, both on a per-patient basis and a per-lesion basis; MRI had the highest specificity on a per-lesion basis. For the subgroup analysis of 18FDG PET, PET/computed tomography was shown to be better than PET and there were no significant differences between using 68Ge and computed tomography for attenuation correction on a per-patient basis.
On a per-lesion basis, the pooled sensitivity estimates for PET, MRI and bone scintigraphy were 95.0, 83.8 and 71.5%, respectively. The pooled specificity estimates for PET, MRI and bone scintigraphy were 94.6, 96.3 and 91.0%, respectively. On a per-patient basis, the pooled sensitivity estimates for PET, MRI and bone scintigraphy were 91.9, 80.0 and 91.8%, respectively.The pooled specificity estimates for PET, MRI and bone scintigraphy were 96.8, 90.6 and 68.8%, respectively.
References:
Tao Liu 1, Jun-Ying Xu y1, Wen Xuz, Yong-Rui Bai x, Wei-Li Yan k, Hui-Lin Yang. Fluorine-18 deoxyglucose Positron Emission Tomography, Magnetic Resonance Imaging and Bone Scintigraphy for the Diagnosis of Bone Metastases in Patients with Lung Cancer: Which One is the Best? - a Meta-analysis. Clinical Oncology (2010), doi:10.1016/j.clon.2010.10.002.