METASTATIC BONE PAIN THERAPY


            Currently this procedure can be conducted using two radiopharmaceuticals. The first one to be introduced was based on 89 Strontium as radionuclide and the second one labelling the tracer with 153 Samarium.

            More recently and still under phase III clinical research it is important to mention chloride 223 radium, an alpha emitter, with less hematological toxicity and which has been suggested to treat bone metastasis in prostatic carcinoma as well (1).

            The properties and use of 89 Strontium and  153 Samarium EDTMP wil be discussed considering the following aspects.

Radiotracer

Protocol

Clinical Applications

References:

1   Liepe K.. Alpharadin, a 223 Ra-based alpha-particle-emitting pharmaceutical for the treatment of bone metastases in patients with cancer. Curr Opin Investig Drugs. 2009 Dec;10(12):1346-58.
 

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