-  In previous days, withdraw somatostatin or a any analog medication. Short acting compounds for 48 h and long acting ones for 6 weeks.

-  Make sure WBC > 2400/ul or Granulocytes > 2000/ul and Platelets > 60.000/ul. Exclude DIC (disseminated intravascular coagulation).

-  Determine blood creatinine concentration to estimate renal function and adjust dose if appropiate. Creatinine clearance should be at least over 30 ml/min.

-  Patient should fast day of therapy.

References:

1  Kwekkeboom Dik J et al. Treatment With the Radiolabeled Somatostatin Analog [177Lu-DOTA0,Tyr3]Octreotate: Toxicity, Efficacy, and Survival. J Clin Oncol 2008; 26: 2124-2130.

2  Reubi J. C. et al. Affinity profiles for human somatostatin receptor subtypes SST1–SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use.  Eur J Nucl Med 2000; 27:273–282.