I-31 MIBG Therapy Administration
- Refer to Dose Estimation for the amount to give. Keep bone marrow radiation dose below 2 Gy.
- I-131 MIBG is given iv in an inpatient basis. Infusion should be administered slowly in 2-3 h.
- If hypertension ensues during the infusion, give propranolol or angiotensin-converting enzyme inhibitors or fenoxibenzamine. Only if these drugs have no effect and according to patient condition give alternatively calcium channel blockers (e.g. sublingual nifedipine).
- Detail in written form radiation protection directions to patient.
Reference:
Diez L, Mitjavila M, Tumores Neuroendocrinos: estudios con meta-yodo-bencil-guanidina, p: 549-561 in: Medicina Nuclear Aplicaciones Clínicas. Eds: I. Carrio - P. González. Editorial Masson, Barcelona España, 2003.