In hospital therapy is optional.

            IV line must be checked thoroughly to avoid infiltration.

            Slow tracer infusion and adequate flushing. If the method is performed on an outpatient basis, it is better to limit close contact with relatives for 24 h, especially early after injection, in particular children and pregnant women.

            At 24 h it can be obtained a whole body image to confirm adequate distribution. Normally, this image is very similar to the 99mTc MDP bone scan, having less activity in kidneys and bladder.

            It is advisable to get blood cell count analysis including platelets at 2, 4 and 6 weeks after radiopharmaceutical administration. In the majority of patients there is a transient and benign bone marrow suppresion, which very unfrequently requires therapy intervention and so  recovering spontaneously.

References:

1 Olea E.G. and Massardo T. Terapia radioisotópica paliativa en el dolor óseo de origen metastásico, p: 563 -569 in: Medicina Nuclear Aplicaciones Clínicas. Eds: I. Carrio - P. González. Editorial Masson, Barcelona España, 2003.

2 Silberstein E. B. Procedure Guideline for Bone Pain Treatment 2.0 p:111-116. Society of Nuclear Medicine, 2002.