Carcinoid Therapy 177Lu-DOTATATE

                     Radiation Doses             (*) Total of 4 to 6 doses, each one every 6-10 weeks.                         (***)

 

            Lutetium-177, emits beta up to 0.5 Mev and gamma radiation most important of 74 Kev, 103 Kev and 208 Kev. As far as power penetration it may reach 20 cell diameter distance (1 mm) compared to 150 cell diameter distance (10 mm) of Itrium-90. The gamma rays of  Lu-177 allow good quality images using the gammacamera, usually obtained 24 h after its administration.

References:

1  Kwekkeboom Dik J et al. Treatment With the Radiolabeled Somatostatin Analog [177Lu-DOTA0,Tyr3]Octreotate: Toxicity, Efficacy, and Survival. J Clin Oncol 2008; 26: 2124-2130.

2  Reubi J. C. et al. Affinity profiles for human somatostatin receptor subtypes SST1–SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use.  Eur J Nucl Med 2000; 27:273–282.

 

Home         Index            Therapy Carcinoid          Therapy Carcinoid Radiotracers