-  It has Type I uptake into the adrenal medulla cells

                -  Active transport into the chromaffin granules.

                -  Any drug interfering in these 2 mechanisms may affect its uptake.

                -  Likewise, any drug displacing catecholamines from within the cell, may decrease MIBG accummulation.

References:

1    Diez L, Mitjavila M, Tumores Neuroendocrinos: Estudios con meta-yodo-bencil-guanidina, p: 549-561 in: Medicina Nuclear Aplicaciones Clínicas. Eds: I. Carrio - P. González. Editorial Masson, Barcelona España, 2003.

2  Hay RV, Scintigraphic Imaging of the Adrenals and Neuroectodermal Tumors, in Henkin RE et al. Nuclear Medicine. Mosby St Louis 1996, p 855-876.