The treatment of choice for pheochromocytoma is surgical, with total excision of the tumor tissue. However, this is not always possible in the case of malignant pheochromocytoma. The incidence of malignant pheochromocytoma at the time of diagnosis is 10%, but it increases when the tumor occurs in young patients and / or location is extraadrenal. After 5 years of evolution of a supposedly benign pheochromocytoma, 50% may develop metastases, suggesting that the malignant potential of pheochromocytomas is underestimated. Compared with other solid tumors pheochromocytoma is a relatively radioresistant tumor. In case of bone metastases  palliative radiation therapy has been used. In general, chemotherapy is ineffective, with a 5-year survival of 40-44%, so there is the initiative of looking for alternative treatments.
 

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